Lipolytic esterase activity of adipose tissue from mice with three types of hereditary obesity☆
Review articleOpen access

AbstractWe have studied lipolytic-active esterases from the epididymal fat pads of mice with hereditary obesities caused by the mutant genes, diabetes (gene symbol, db), obese (ob) and yellow (AY). The AY and ob alleles are maintained in the inbred strain C57BLJ6J, and the db allele is propagated in the related strain C57BL/KsJ. The effect of each mutation on lipolytic esterase activity was determined by comparing agarose gel zymograms of mutant with non-mutant normal mice. The AY allele did not alter the isozyme pattern of at least five bands characteristically present in normal mice. Isozyme deletions occurred in diabetic mice of C57BL/KsJ-ob and obese mice of C57BL/6J-ob. These findings suggest that the pathogenesis of obesity caused by the AY allele differs from that of the db and ob alleles; apparently, a major abnormality in db and ob concerns lipolysis.

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