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Original paperSynthesis and nidation inhibitory activity of a new class of ergoline derivativesSynthèse et activité inhibitrice sur la nidation d'une nouvelle classe de dérivés de l'ergoline

Enzo Brambilla - No affiliation found

1989/07/01 Full-length article DOI: 10.1016/0223-5234(89)90087-1 Journal: European Journal of Medicinal Chemistry

Abstract:

AbstractThe synthesis and the nidation inhibitory activity (indirect evidence of prolactin activity) of a new class of ergolinyl-acylureas is described. Some structure—activity relationship considerations are also reported. N-[3-(Dimethyl-amino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8β-carboxamide (laboratory code FCE 21336; international non-proprietary name cabergoline) was the most interesting compound of the series and is now under extensive clinical evaluation in treatment of hyperprolactinemic disorders.