Original paperSynthesis and nidation inhibitory activity of a new class of ergoline derivativesSynthèse et activité inhibitrice sur la nidation d'une nouvelle classe de dérivés de l'ergoline
Review articleOpen access

AbstractThe synthesis and the nidation inhibitory activity (indirect evidence of prolactin activity) of a new class of ergolinyl-acylureas is described. Some structure—activity relationship considerations are also reported. N-[3-(Dimethyl-amino)propyl]-N-[(ethylamino)carbonyl]-6-(2-propenyl)ergoline-8β-carboxamide (laboratory code FCE 21336; international non-proprietary name cabergoline) was the most interesting compound of the series and is now under extensive clinical evaluation in treatment of hyperprolactinemic disorders.

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