The cholecystokinin antagonist, proglumide, increases food intake in the rat
Review articleOpen access
1984/04/01 Full-length article DOI: 10.1016/0167-0115(84)90058-2
Journal: Regulatory Peptides
AbstractCholecystokinin, secreted in response to ingested food entering the duodenum, may play a role in limiting food intake. Inhibition of cholecystokinin should therefore induce an increase in food intake. Proglumide, a specific antagonist of cholecystokinin was used to block the satiety effect of a food preload in rats. A significant increase in food intake was obtained following proglumide injection, thus supporting the hypothesis that cholecystokinin, released by food in the duodenum, acts as a short-term satiety factor.
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