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ReviewTracing the cellular expression of neuromodulatory genes

J.L. Noebels - No affiliation found

1985/01/01 Review article DOI: 10.1016/0166-2236(85)90114-6 Journal: Trends in Neurosciences

Abstract:

AbstractNovel strategies in molecular biology can now isolate single genes unique to central neurons. A parallel approach to identify loci which determine specific excitability patterns in the brain, presents a complementary framework to explore gene expression within the developing mammalian central nervous system. A search for mutations in mice with abnormal cortical synchronization is a simple method to isolate functional neuromodulatory loci and to examine molecular diseases of neuronal integration at a cellular level. Analysis of one of these genes, tg, is beginning to yield unexpected clues into mechanisms of inherited epileptogenesis.