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Genetic damage in Salmonella typhimurium by near-ultraviolet radiation: Lack of repair by plasmid pKM101

A. Eisenstark - No affiliation found

1983/12/01 Full-length article DOI: 10.1016/0165-7992(83)90005-2 Journal: Mutation Research Letters

Abstract:

AbstractPlasmid pKM101, whose mucA and B genes endow cells with enhanced mutation frequency and enhanced resistance to far-ultraviolet radiation (FUV) (254 nm), had no influence on these properties when cells were damaged by near-ultraviolet radiation (NUV) (300–400 nm). Thus, NUV lesions did not lead to induction of SOS repair and subsequent expression of mucA and B genes on plasmid pKM101. Further, when cells were pre-irradiated with NUV and subsequently irradiated with FUV, there was a blockage of SOS repair, including the repair normally controlled by genes on pKM101.