Short reportsLow-dose allopurinol plus azathioprine/ cyclosporin/prednisolone, a novel immunosuppressive regimen
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AbstractEarly rejection can still complicate renal transplantation even with cyclosporin. We added low-dose allopurinol (25 mg on alternative days) to “triple” immunosupression with cyclo- sporin, prednisolone,and azathioprine for twelve recipients of cadaver renal grafts. The controls were fifteen patients on triple therapy alone. Only one rejection episode occured among the allopurinol-treated patients, whereas eleven con- trols had rejections (seven with more than one episode). Allopurinol may be toxic when combined with azathioprine, yet the bone marrow tolerated the new regimen well. As expected, reduction of the azathiprine dose was necessary in the treated group. Lancet 1993; 342: 83–84

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