Digestive EndoscopyTreatment of malignant gastroduodenal obstruction with a nitinol self-expanding metal stent: An international prospective multicentre registry
Review articleOpen access

AbstractBackgroundDuodenal stenting has become a broadly accepted first line of treatment for patients with advanced malignant gastroduodenal obstruction as these patients are difficult to treat and are poor surgical candidates.AimsTo document duodenal stent performance for palliative management of malignant gastroduodenal obstruction.MethodsMulticentre, single arm, prospective registry documenting peroral endoscopic duodenal stenting procedures in 202 patients.ResultsTechnical success achieved in 98% (CI, 95%, 99%) of stent placements. Increase of Gastric Outlet Obstruction Score by at least 1 point compared to baseline was achieved in 91% (CI, 86%, 95%) of patients persisting for a median of 184 days (CI, 109, 266). By day 5 (CI, 4, 6) after stent placement, 50% of patients experienced a score increase of at least 1 point.Improvement from 14% of patients at baseline tolerating soft solids or low residue/normal diet to 84% at 15 days, 86% at 30 days, 81% at 90 days, 79% at 180 days, and 70% at 270 days. Complications included stent ingrowth and/or overgrowth (12.4%), transient periprocedural symptoms (3%), bleeding (3%), stent migration (1.5%), and perforation (0.5%).ConclusionsSafety and effectiveness of duodenal stenting for palliation of malignant gastroduodenal obstruction was confirmed in the largest international prospective series to date.

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