The effect of pilocarpine stimulation on the histologic appearance and the sodium and potassium content of rat submaxillo-sublingual glands☆
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AbstractAfter the administration of graded doses of pilocarpine to Wistar rats, the following effects were observed: 1.1. Mean sodium levels were in all instances significantly higher in the treated animals than in the controls, while the reverse held true for the gland potassium content. The sodium/potassium ratio was consistently higher in the pilocarpine-treated groups.2.2. There was no observable histologic change in the mucous acini of the sublingual gland after pilocarpine. The acini of the submaxillary glands showed marked changes after pilocarpine; there was a decrease in the amount of cytoplasm so that the nuclei appeared closely packed, there was less distraction of the individual acinus, and there was greater prominence of the ducts.

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