Hycanthone as a specific frameshift mutagen in Saccharomyces cerevisiae
Review articleOpen access
Abstract:

AbstractReversion of mutations of different molecular nature was studied after treatment with hycanthone in mild conditions (0.05–0.4 mM, 4 h in the dark, pH 7.2). The mutagen had a very low reversion activity on 3 missense and 4 nonsense mutations (2 UAA and 2 UAG), although it was very active on 3 frameshift mutations. Our data on intragenic reversion and frameshift suppressors indicate that hycanthone can induce both insertions and deletions.

Request full text

References (0)

Cited By (0)

No reference data.
No citation data.
Advertisement
Join Copernicus Academic and get access to over 12 million papers authored by 7+ million academics.
Join for free!