Hycanthone as a specific frameshift mutagen in Saccharomyces cerevisiae
Review articleOpen access
1980/08/01 Full-length article DOI: 10.1016/0027-5107(80)90114-1
Journal: Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
AbstractReversion of mutations of different molecular nature was studied after treatment with hycanthone in mild conditions (0.05–0.4 mM, 4 h in the dark, pH 7.2). The mutagen had a very low reversion activity on 3 missense and 4 nonsense mutations (2 UAA and 2 UAG), although it was very active on 3 frameshift mutations. Our data on intragenic reversion and frameshift suppressors indicate that hycanthone can induce both insertions and deletions.
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