ReviewNucleolar Function in Lifespan Regulation
Review articleOpen access
Abstract:

HighlightsThe nucleolus is an intranuclear organelle primarily involved in ribosomal RNA synthesis and ribosome assembly, but also functions in the assembly of other important ribonucleoprotein particles that affect all levels of information processing.Recent evidence has highlighted novel roles of the nucleolus in major physiological functions including stress response, development, and aging.Signaling pathways that regulate organismal lifespan converge on nucleolar size and function, and implicate nucleolar function with aging.Exploring the detailed function of the nucleolus in aging can contribute to understanding the molecular mechanisms behind longevity and premature aging disorders.

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