A touching case of channel regulation: the ATP-sensitive K+ channel
Review articleOpen access
1998/06/01 Full-length article DOI: 10.1016/S0959-4388(98)80055-X
Journal: Current Opinion in Neurobiology
AbstractThe classical type of KATP channel is an octameric (4:4) complex of two structurally unrelated subunits, Kir6.2 and SUR. The former serves as an ATP-inhibitable pore, while SUR is a regulatory subunit endowing sensitivity to sulphonylurea and K+ channel opener drugs, and the potentiatory action of MgADP. Both subunits are required to form a functional channel.
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