Fibronectin fibrils regulate TGF-β1-induced Epithelial-Mesenchymal Transition
Review articleOpen access
2017/07/01 Full-length article DOI: 10.1016/j.matbio.2017.01.001
Journal: Matrix Biology
Highlights•Inhibition of FN fibril formation blocks Epithelial–Mesenchymal Transition (EMT)•Increasing soluble FN or assembling FN fibrils without TGF–b1 doesn't induce EMT.•Inhibiting the localization of TGF–b1 to assembled FN fibrils blocks EMT•These suggest that FN fibrils facilitate EMT by clustering TGF–b1 at the cell surface.
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