Topical co-delivery of methotrexate and etanercept using lipid nanoparticles: A targeted approach for psoriasis management
Review articleOpen access

Highlights•Cetyl palmitate SLNs with MTX and functionalized with etanercept were synthesized.•Enhanced skin deposition of MTX when incorporated within SLNs in relation to free drug.•The carbopol hydrogel increased the MTX retention time within the skin.•Therapeutic amounts of MTX were delivered to psoriatic human skin through SLNs.

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