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The serpent gene is necessary for progression through the early stages of fat-body development

Sima Sam - No affiliation found

1996/12/01 Full-length article DOI: 10.1016/S0925-4773(96)00615-6 Journal: Mechanisms of Development

Abstract:

AbstractThe serpent (srp) gene, also known as ABF, codes for a GATA-like transcription factor and is involved in the transcriptional activation of Adh in the larval fat body or adipose tissue. Here, we describe the tissue-specific distribution of SRP protein in various stages of embryonic development and describe srp's role in early fat-cell development. SRP protein was detected in the progenitor fat-body cells and is present in the developing fat-body cells and in the mature embryonic fat body. An analysis of srp embryos revealed a gradual loss of precursor fat cells that is likely due to apoptosis. Within the fat-cell lineage, srp is necessary for progression through early stages of fat-cell development and may be involved in the transactivation of genes necessary for fat-cell differentiation.