Original articleMuscle-derived extracellular superoxide dismutase inhibits endothelial activation and protects against multiple organ dysfunction syndrome in mice
Review articleOpen access
Abstract:

Highlights•Increased EcSOD in vital organs from skeletal muscle protects against MODS.•EcSOD mutation mimicking human R213G SNP exacerbates MODS.•Parabiosis and serum transfusion confirm causation of EcSOD in protection.•The mechanism is inhibition of endothelial activation in endotoxemia.

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