Zerumbone modulates CD1d expression and lipid antigen presentation pathway in breast cancer cells
Review articleOpen access

Highlights•CD1d expression increases with advanced stages of breast cancer cells.•Zerumbone inhibited CD1d antigen presentation pathway including CD1d expression.•α-GalCer enhanced CD1d as well as survival and proliferation of breast cancer cells.•CD1d-mediated cell survival was likely through ERK1/2 and Akt pathways.•CD1d blockade led apoptosis and cell cycle arrest; further enhanced by zerumbone.

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