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Zerumbone modulates CD1d expression and lipid antigen presentation pathway in breast cancer cells

Ritis K. Shyanti - No affiliation found

2017/10/01 Full-length article DOI: 10.1016/j.tiv.2017.06.016 Journal: Toxicology in Vitro

Abstract:

Highlights•CD1d expression increases with advanced stages of breast cancer cells.•Zerumbone inhibited CD1d antigen presentation pathway including CD1d expression.•α-GalCer enhanced CD1d as well as survival and proliferation of breast cancer cells.•CD1d-mediated cell survival was likely through ERK1/2 and Akt pathways.•CD1d blockade led apoptosis and cell cycle arrest; further enhanced by zerumbone.