Zerumbone modulates CD1d expression and lipid antigen presentation pathway in breast cancer cells
Review articleOpen access
2017/10/01 Full-length article DOI: 10.1016/j.tiv.2017.06.016
Journal: Toxicology in Vitro
Highlights•CD1d expression increases with advanced stages of breast cancer cells.•Zerumbone inhibited CD1d antigen presentation pathway including CD1d expression.•α-GalCer enhanced CD1d as well as survival and proliferation of breast cancer cells.•CD1d-mediated cell survival was likely through ERK1/2 and Akt pathways.•CD1d blockade led apoptosis and cell cycle arrest; further enhanced by zerumbone.
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