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Stress-altered synaptic plasticity and DAMP signaling in the hippocampus-PFC axis; elucidating the significance of IGF-1/IGF-1R/CaMKIIα expression in neural changes associated with a prolonged exposure therapy

Olalekan M. Ogundele - No affiliation found

2017/06/14 Full-length article DOI: 10.1016/j.neuroscience.2017.04.008 Journal: Neuroscience

Abstract:

Highlights•Prolonged exposure therapy reduces anxiety-linked behavior in naïve stressed rats.•In Stress and Stress-PET, a phasic change in IGF-1R was linked with a depletion of CaMKIIα.•Chronic stress exposure caused synaptic changes involving an upregulation of small ion conductance channels (KCa2.2).•Prolonged exposure therapy increased brain microglia activation past the naïve stress level.