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Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia

Gustavo José Leirós - No affiliation found

2017/01/05 Full-length article DOI: 10.1016/j.mce.2016.10.018 Journal: Molecular and Cellular Endocrinology

Abstract:

Highlights•Androgens alter Wnt agonists/antagonists expression balance in dermal papilla.•In dermal papilla cells (DPC) spheroids, Wnt agonists basal expression is favored.•DKK-1 mimicked androgen inhibition on hair follicle stem cell (HFSC) differentiation.•WNT10b overcame androgen inhibition of HFSC differentiation.•Androgen action on DPC inhibits Wnt pathway in hair follicle differentiating cells.