Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia
Review articleOpen access
Abstract:

Highlights•Androgens alter Wnt agonists/antagonists expression balance in dermal papilla.•In dermal papilla cells (DPC) spheroids, Wnt agonists basal expression is favored.•DKK-1 mimicked androgen inhibition on hair follicle stem cell (HFSC) differentiation.•WNT10b overcame androgen inhibition of HFSC differentiation.•Androgen action on DPC inhibits Wnt pathway in hair follicle differentiating cells.

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