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The amyloidogenicity of the influenza virus PB1-derived peptide sheds light on its antiviral activity

Yana A. Zabrodskaya - No affiliation found

2018/03/01 Full-length article DOI: 10.1016/j.bpc.2018.01.001 Journal: Biophysical Chemistry

Abstract:

Highlights•PB1(6–13) peptide is prone to form the amyloid-like fibrils.•PB1(6–13) is able to interact with influenza A virus PB1 N-terminus in peptide model.•Peptide induces the conformational transition in PB1 N-terminus in peptide model.•The results allow us to hypothesize a mechanism of PB1(6–13) antiviral action.