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Melatonin attenuates cisplatin-induced acute kidney injury in rats via induction of anti-aging protein, Klotho

Je-Won Ko - No affiliation found

2019/07/01 Full-length article DOI: 10.1016/j.fct.2019.04.049 Journal: Food and Chemical Toxicology

Abstract:

Highlights•Melatonin (MT) attenuated acute kidney injury induced by cisplatin (CP).•MT upregulated the expression level of Klotho decreased by CP treatment.•Upregulated Klotho attenuated oxidative stress and apoptosis induced by CP.