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Clostridium difficile chimeric toxin receptor binding domain vaccine induced protection against different strains in active and passive challenge models

Jing-Hui Tian - No affiliation found

2017/07/24 Full-length article DOI: 10.1016/j.vaccine.2017.06.062 Journal: Vaccine

Abstract:

Highlights•A chimeric fusion protein vaccine protects against C. difficile infection (CDI).•Tetravalent toxin vaccine is effective against hypervirulent C. difficile.•The vaccine was used to produce hyperimmune human antitoxin IgG in transgenic bovine.•Human antitoxin IgG has potential to treat and prevent recurrent CDI.