Pre-clinical immunogenicity of human papillomavirus alpha-7 and alpha-9 major capsid proteins
Review articleOpen access

Highlights•Comprehensive pre-clinical immunogenicity evaluation of HPV L1 major capsid protein.•Majority neutralizing antibody response was genotype-specific.•Reciprocal cross-neutralization between some Alpha-7 and Alpha-9 genotypes.•Tetravalent formulation (HPV16/18/39/58) induced broadly neutralizing antibodies.•These data improve our understanding of the antigenic diversity of the L1 protein.

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