Short communicationDevelopment of pneumococcal polysaccharide conjugate vaccine with long spacer arm
Review articleOpen access

Highlights•CuAAC chemistry can efficiently prepare pneumococcal polysaccharide (PS) conjugate vaccine.•Long spacer arm can minimize the problem of steric hindrance between carrier protein and PS.•Long spacer arm can improve the polysaccharide-specific antibody titers elicited by conjugate vaccine.

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