Short communicationDevelopment of pneumococcal polysaccharide conjugate vaccine with long spacer arm
Review articleOpen access
Abstract:

Highlights•CuAAC chemistry can efficiently prepare pneumococcal polysaccharide (PS) conjugate vaccine.•Long spacer arm can minimize the problem of steric hindrance between carrier protein and PS.•Long spacer arm can improve the polysaccharide-specific antibody titers elicited by conjugate vaccine.

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