Bulb extracts of Boophone disticha induce hepatotoxicity by perturbing growth, without significantly impacting cellular viability
Review articleOpen access
W. Cordier - No affiliation found
2018/01/01 Full-length article DOI: 10.1016/j.sajb.2017.10.005
Journal: South African Journal of Botany
Highlights•The methanol extract of Boophane disticha bulbs is more cytotoxic than the hot water extract.•Both extracts follow a similar mechanism of cytotoxicity.•Mitochondrial depolarisation occurs, with no oxidative stress.•Fatty acid accumulation is present, which may predispose cells to steatotic changes.•Cell growth is diminished, however, little cell death occurs.
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