Bulb extracts of Boophone disticha induce hepatotoxicity by perturbing growth, without significantly impacting cellular viability
Review articleOpen access
Abstract:

Highlights•The methanol extract of Boophane disticha bulbs is more cytotoxic than the hot water extract.•Both extracts follow a similar mechanism of cytotoxicity.•Mitochondrial depolarisation occurs, with no oxidative stress.•Fatty acid accumulation is present, which may predispose cells to steatotic changes.•Cell growth is diminished, however, little cell death occurs.

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