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Cathepsin B inhibitory peptides derived from β-casein☆

Hyun Sook Lee - No affiliation found

2000/06/01 Full-length article DOI: 10.1016/S0196-9781(00)00212-6 Journal: Peptides

Abstract:

AbstractTwo cathepsin B inhibitory peptides were isolated from a commercial pancreatic digest of casein. The peptides were identified as the Pro-Phe-Pro-Gly-Pro-Ile and the Gly-Pro-Phe-Pro-Ile corresponding to the sequence 61–66 and 203–207 of bovine β-casein. These peptides showed competitive inhibition for cathepsin B with the Ki values of 2.31 and 3.30 mM, respectively. Two related analogues, Tyr-Pro-Phe-Pro-Gly-Pro-Ile and Val-Tyr-Pro-Phe-Pro-Gly-Pro-Ile, were synthesized but their cathepsin B inhibitory activity was not detected.