Inhibition of rubella virus replication by the broad-spectrum drug nitazoxanide in cell culture and in a patient with a primary immune deficiency
Review articleOpen access
Abstract:

Highlights•Empiric therapy with oral NTZ resulted in the elimination of RV antigen from RV positive granulomas in a PID patient.•We investigated the anti-RV activities of NTZ in cell culture and its mechanisms of action.•The drug interferes with E1-E2 intracellular trafficking and inhibits synthesis of cellular RNAs and viral RNAs.

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