Amniotic fluid tests for fetal maturity☆
Review articleOpen access

AbstractEighteen biochemical parameters and one cytologic test (percentage of lipid-positive cells) in amniotic fluid were assessed for their value in establishing fetal maturity. Ten parameters showed a trend with gestation but the three best tests were percentage of lipid-positive cells, lecithin/sphingomyelin ratio (L/S), and creatinine. With the use of a graph containing the mean value of the three key parameters, an estimated period of gestation was produced which was 95 per cent accurate for any individual sample. With some minor deviations the three tests and the estimated period of gestation based on the three tests continued to be accurate in abnormal pregnancy states.

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