Pupil responses and pain ratings to heat stimuli: Reliability and effects of expectations and a conditioning pain stimulus
Review articleOpen access
Abstract:

Highlights•Acute changes in pupil diameter reflect changes in locus coeruleus activity.•Pupil dilation occurs in response to noxious stimulation, but the effect of heat stimuli on pupil response has not been tested.•In volunteers, pupil dilation correlates with heat temperature and with pain intensity.•The relationship between pupil dilation and pain intensity report is disrupted when cognitive load is increased.

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