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Synthesis of biocompatible polymeric nano-capsules based on calcium carbonate: A potential cisplatin delivery system

Viviana Vergaro - No affiliation found

2015/12/01 Full-length article DOI: 10.1016/j.jinorgbio.2015.10.014 Journal: Journal of Inorganic Biochemistry

Abstract:

Highlights•Alginic acid/protamine (ALG/PRM) nanocapsules give loading efficiency and fast uptake.•The fastest uptake of nanocapsules is obtained for the human mammarian MCF-7 cell line.•Nanocapsules' intracellular localization is perinuclear for the four examined cell lines.•Loaded capsules have comparable cytotoxicity to free cisplatin at similar concentrations.