Placental enzymes: Specific activities and isoenzyme patterns during early and late gestation
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AbstractThe specific activities and the isoenzyme patterns of 6 enzymes—lactate dehydrogenase, glucose dehydrogenase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, β-glucuronidase, and N-acetyl-β-glucosaminidase—were studied in extracts from first-trimester, second-trimester, and term placentas. All 6 enzymes were present in all specimens. Significant decreases were noted in the specific activity of glucose-6-phosphate dehydrogenase in the second trimester relative to the first, of 6-phosphogluconate dehydrogenase in the second trimester relative to both the first trimester and term, and of N-acetyl-β-glucosaminidase at term relative to both the first and second trimesters. Isoenzyme patterns of 5 of the enzymes were basically unchanged from the first trimester to term. Lactate dehydrogenase showed an additional isoenzyme in first-trimester zymograms; it also exhibited marked shifts in relative isoenzyme intensities between the first trimester and term.

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