Transactions of the Twenty-fifth Annual Meeting of the Society of Obstetricians and Gynaecologists of CanadaCreatinine, uric acid, and electrolytes in amniotic fluid☆
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AbstractFour hundred samples of amniotic fluid obtained by amniocentesis, mostly from Rh-sensitized patients, were analyzed for creatinine, uric acid, sodium, potassium, and chloride. Amniotic fluid creatinine values were below 1 mg. per 100 ml. before 28 weeks and about 2 mg. per 100 ml. close to term. Eighty-six per cent of all creatinine values at 37 weeks' gestation or more were at or above 1.6 mg. per 100 ml. Serial creatinine values in stillbirths were generally low and showed a decline. There was good correlation between creatinine values and both birth weight and maturity of infants born within one week of amniocentesis. Amniotic fluid uric acid increased with gestational age with a fairly wide scatter. Values for sodium and chloride stayed approximately in the range of those for normal serum with a slight progressive fall to term. Potassium values stayed within normal serum values but showed a slight rise to term. Amniotic fluid creatinine showed the most definite trend with gestational age and thus is a useful test for fetal maturity.

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