Effects of estradiol on lactoprivic signaling of the hindbrain upon the contraregulatory hormonal response and metabolic neuropeptide synthesis in hypoglycemic female rats
Review articleOpen access
Abstract:

Highlights•Ovariectomized female rats were replaced with estradiol (E) at estrous cycle nadir or peak levels.•Rats were injected with insulin or vehicle after start of caudal fourth ventricular L-lactate infusion.•Lactate fully or partially reversed hypoglycemic hyperglucagonemia and -corticosteronemia.•Lactate caused dissimilar changes in dorsomedial hypothalamic norepinephrine between E groups.•E signal strength defines unique metabolic transmitter targets of lactoprivic signals.

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