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Propargylamine (secondary) as a building block in indole synthesis involving ultrasound assisted Pd/Cu-catalyzed coupling-cyclization method: Unexpected formation of (pyrazole)imine derivatives

Gangireddy Sujeevan Reddy - No affiliation found

2018/12/26 Short communication DOI: 10.1016/j.tetlet.2018.11.037 Journal: Tetrahedron Letters

Abstract:

Highlights•Explored the rare use of propargylamine as a building block in the Pd/Cu catalyzed synthesis of indoles under ultrasound.•Indoles containing a pyrazole moiety at C-2 attached via the –CH2NH– linker were synthesized as anti-tubercular agents.•Synthesized related (pyrazole)imines via a Cu catalyzed ultrasound assisted aerobic oxidation of precursor amines.