Liquid phase synthesis of chiral quinoxalinones by microwave irradiation
Review articleOpen access
2004/02/02 Short communication DOI: 10.1016/j.tetlet.2003.12.056
Journal: Tetrahedron Letters
Abstract:
AbstractSingle mode microwave-assisted combinatorial synthesis of biologically interesting quinoxalinones is described. Chiral libraries of quinoxalinone were readily assembled utilizing SNAr reactions, reduction and followed with concomitant cyclization under microwave irradiation. Enantiomeric 1,2,3,4-tetrahydroquinoxalinones were isolated in excellent yield and purity after cleavage.
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