Total synthesis of thienamycin analogs—III : Syntheses of 2-aryl and 2-heteroaryl analogs of thienamycin
Review articleOpen access
Abstract:

AbstractThe total syntheses of 2-aryl and 2-heteroaryl carbapen-2-em-3-carboxylic acids with and without a 6-hydroxyethyl side chain, using a Wittig cyclization for formation of the bicyclic ring system is described. Antibacterial activity of the compounds synthesized is discussed.

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