Stereoselective synthesis of 2(S)-(1,1-dimethylethylsulfonylmethyl)-3-(1-naphthyl)-propionic acid, building block for protease inhibitors via asymmetric hydrogenation
Review articleOpen access
Abstract:

AbstractTitle compound 1b (purity > 99%, 99.6%ee) is synthesized (100g scale) from commercial 3-bromo-pyruvic acid in six steps with an overall yield of 16%. The sequence is operationally simple and devoid of chromatographic purifications. Key step is the asymmetric hydrogenation of a substrate with substrate with functionality.

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