An antiserum to the C-terminus of the Alzheimer amyloid precursor recognizes a soluble 70 kDa protein
Review articleOpen access
1988/09/12 Full-length article DOI: 10.1016/0014-5793(88)80200-X
Journal: FEBS Letters
AbstractA rabbit antiserum to the C-terminus of the putative brain amyloid precursor was used to probe Western blots of tissue proteins separated by SDS-PAGE. The antiserum specifically labelled a protein of approx. 70 kDa in the Tris buffer-soluble fraction of brain samples from rat, Alzheimer subjects, cases of young and old Down's syndrome, and age-matched controls. The 70 kDa protein was present in low concentrations in human liver and kidney, and was undetectable in human skeletal muscle. The 70 kDa protein may be a metabolite of the amyloid precursor.
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