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Changes in gene transcription and taxane production in elicited cell cultures of Taxus × media and Taxus globosa

Karla Ramirez-Estrada - No affiliation found

2015/09/01 Full-length article DOI: 10.1016/j.phytochem.2015.06.013 Journal: Phytochemistry

Abstract:

Highlights•Taxol and baccatin III production was higher in T. media than T. globosa cells.•T. media cell cultures increased taxol production 80-fold when treated with CD + CORO.•T. globosa cells excreted more than 90% of their taxanes to the medium.•A limiting step of taxol biosynthesis is probably controlled by the BAPT gene.•Taxol biosynthetic gene expression was enhanced in CD + CORO-treated T. media cells.