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Dopaminergic and cholinergic regulation of Fyn tyrosine kinase phosphorylation in the rat striatum in vivo

Li-Min Mao - No affiliation found

2015/12/01 Full-length article DOI: 10.1016/j.neuropharm.2015.08.017 Journal: Neuropharmacology

Abstract:

Highlights•A dopamine D1 receptor (D1R) agonist increased Fyn phosphorylation in the striatum.•A positive modulator of muscarinic M4 receptors (M4R) inhibited this increase.•D1Rs increased tyrosine phosphorylation of GluN2B, while M4Rs decreased it.•D1Rs and M4Rs form a balance regulating Fyn and NMDA receptors in striatal neurons.