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Complications After Intravesical Instillation of Bacillus Calmette-guerin: Rhabdomyolysis and Metastatic Infection

R.W. Armstrong - No affiliation found

1991/06/01 Full-length article DOI: 10.1016/S0022-5347(17)38596-8 Journal: The Journal of Urology

Abstract:

AbstractTwo cases of adverse reaction to bacillus Calmette-Guerin (BCG) bladder instillations are reported. In both cases transient fevers and systemic symptoms developed following the instillations. After an additional instillation 1 patient had high fevers, severe myalgias and profound weakness followed by rhabdomyolysis and anuric renal failure, which required 3 weeks of hemodialysis before recovery. Extensive evaluation revealed no cause other than the BCG instillations. In the other patient a firm subcutaneous nodule gradually developed on the chest wall, which contained nonviable acid fast bacilli.