NotesSaluretic Action of Ethacrynic Acid in the Mouse
Review articleOpen access

The new saluretic-diuretic agent, ethacrynic acid, has been reported to be inactive in the rat. It was examined for activity in another rodent, the mouse, an animal frequently used for the initial screening of biological activity of new agents. This agent was found to produce a dose-related increase in the excretion of sodium and chloride ions. These data indicate that the saluretic-diuretic activity of ethacrynic acid would have been detectable in an initial evaluation of this agent in the mouse.

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