Research ArticlePharmacological Evaluation of a Series of 3,6-Substituted Pyridazine Derivatives
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A series of 3,6-substituted pyridazine derivatives were tested for central pharmacologic activity. On the basis of their effects on gross behavior, spontaneous, and forced motor activity of albino mice, the alkoxy-pyridazine derivatives were characterized as CNS depressants, while the alkoxy-2-dimethylaminoethoxy-pyridazine derivatives produced initial stimulation followed by a depression of spontaneous activity. The latter compounds also shortened hexobarbital sleeping time in mice and induced a low-voltage fast-wave activity in the electrocorticogram of the cat. None of the compounds produced any alteration of avoidance escape responding in mice or rats or caused a significant inhibition of convulsions produced by chemo- or electrostimulation in rats. A substudy indicated that there was little or no species difference in the learning ability or the response to chlorpromazine of mice and rats in the conditioned avoidance response test (pole climbing).

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