Original articleLocalization of sodium channel subtypes in mouse ventricular myocytes using quantitative immunocytochemistry
Review articleOpen access
Abstract:

Highlights•Methods for quantifying Na channel α subunit immunostaining are described.•Nav1.5 accounts for 77% of Na channels in mouse ventricular myocytes.•Nav1.1, Nav1.3, Nav1.4 and Nav1.6 account for the remaining 23%.•Nav1.5 is expressed on the cell surface and concentrated at intercalated discs.•Nav1.1 and Nav1.3 but not Nav1.5 are expressed in transverse tubules.

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