Original ArticleBehavior of Virus in Malignant Degeneration of Skin Lesion in Epidermodysplasia Verruciformis
Review articleOpen access

An intranuclear virus identical with or closely related to that of verruca vulgaris was demonstrated previously by the authors in epidermodysplasia verruciformis. The behavior of the virus in malignant degeneration of these skin lesions was studied by electron microscopy. Virus-containing cells could be demonstrated in intra-epidermal carcinomas, probably originating from the original cutaneous lesion. In contrast with these findings no virus-containing cells could be demonstrated after careful examination of an invasive “bowenoid” squamous cell carcinoma which histologically showed some features of an original e.v. lesion (epithelioma epidermodysplasique). A similar behavior of virus is known in malignant changes induced by polyoma virus in animals. The establishment of a possible relationship between virus and carcinogenesis was not within the scope of the investigations reported.

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