Chapter 31 - Novel and Emerging Surveillance Markers for Bladder Cancer
Review articleOpen access

AbstractA high likelihood of recurrence of bladder cancer has made the development of urinary markers a focus of intense pursuit with the hope of decreasing the burden which this disease places on patients and the healthcare system. Interests include the development of a single urinary marker that can be used in place of or as an adjunct to surveillance techniques, as well as identifying a molecular signature for an individual’s disease that can help predict progression, prognosis, and potential therapeutic response. Markers have shown potential value in improving diagnostic accuracy when used as an adjunct to current modalities, risk stratification of patients that could aid the clinician in determining aggressiveness of surveillance, and allowing for a decrease in invasive surveillance procedures. This review discusses the current understanding of emerging biomarkers, including gene signatures and their potential clinical value in surveillance tools, as well as limitations to their incorporation into medical practice.

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